Research

What does research mean?

Research represents the process of scientific work and gaining scientific knowledge along with information. It features a specific, orderly approach and is always set on a particular goal. While random searches can also lead to discoveries, research projects require analysis as well as an understanding of the results in general together with a structured approach.

Internal research Cannerald

Our research interests can be categorized into the study of cannabis cultivation and investigations into the therapeutic applications of metabolites derived from these plants. Thanks to advances in genetic engineering, most of the cannabis chemotype traits have been deciphered at the genomic level.

However, the variability of the metabolite profile within a cultivar cannot be explained solely by the presence or absence of genes responsible for the production of these metabolites in the plants. Consequently, to explain the variability of the metabolite profile, an analysis at the transcriptional level is required.

A systematic analysis of factors responding to external stimuli should provide insight into changes in metabolite profile observed within cultivars with high variability. With this understanding of the mechanisms leading to plasticity, we can develop tools to positively influence these processes. This will help produce high-quality cannabis plants with increasingly consistent metabolite profiles.

In this regard, cannabis is a valuable source of chemical compounds having various structures and exhibiting diverse pharmacological effects. The latter result from the affinity of these compounds primarily for the receptors of the endocannabinoid system, but also for other receptors.

The complex molecular composition of cannabis makes it challenging to assign therapeutic effects to individual compounds.

On the one hand, our research, therefore, focuses on the isolation of active constituents, systematic recombination, and concentration-dependent analysis of effects in vitro: On the other hand, cohort studies with medicinal cannabis are conducted under the guidance of clinicians to evaluate the therapeutic effects. These methods are necessary to assess the pharmacokinetic and -dynamic properties and better understand the molecular mechanisms at the cellular level. Based on this knowledge, new varieties - each with their particular metabolite profile - will be cultivated for treating specific diseases. (Dr. Pascal Röthlisberger, Head of Research, Cannerald AG)